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The way in which pathogens act on the organism and the way in which they lead to pathological changes in the organism is called pathogenesis. If the organism is affected by any etiological factor of sufficient strength and if all the necessary conditions (predisposition) are created, pathological disorders will develop in the organism, the set of which gives a picture of the disease.

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Jaundice can occur whenever this normal process of destruction of red blood cells and elimination of bilirubin is interrupted. This occurs when there is abnormally increased destruction of red blood cells (hemolysis), liver disease that reduces the ability of the liver to remove and modify bilirubin, or obstruction to the flow of bile into the intestine.

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